Which of the following conditions is associated with Nikolsky's sign?

Nikolsky's sign is a clinical finding characterized by the ability to induce blistering of the skin with minimal pressure on the skin surface. This sign is primarily associated with conditions characterized by loss of adhesion between epidermal cells.

The correct answer is associated with Staphylococcal scalded skin syndrome (SSSS). SSSS is caused by toxins produced by Staphylococcus aureus, which lead to the disruption of desmosomal connections in the skin, resulting in widespread exfoliative dermatitis. The presence of Nikolsky's sign in this condition indicates that the epidermis can be easily detached from the underlying layers, which is consistent with the pathology of SSSS.

In contrast, Bullous pemphigoid is typically characterized by subepidermal blisters and usually does not demonstrate Nikolsky's sign because the blister formation is due to immune-mediated attacks on hemidesmosomes rather than a loss of adhesion between epidermal cells.

Pemphigus foliaceus, on the other hand, does involve the disruption of adhesion between keratinocytes and is known to show Nikolsky's sign; however, this condition primarily presents with superficial blisters, distinctly different from the widespread involvement seen in SSSS.

Contact dermatitis