Which antibiotic is known for having good coverage against MRSA?

Tigecycline is known for having good coverage against Methicillin-resistant Staphylococcus aureus (MRSA). Tigecycline is a glycylcycline antibiotic that belongs to the tetracycline class and has a broad spectrum of activity. Its structure allows it to bind effectively to bacterial ribosomes, inhibiting protein synthesis and demonstrating efficacy against a variety of Gram-positive and Gram-negative bacteria, including MRSA.

In clinical practice, MRSA infections can be challenging to treat due to their resistance to many commonly used antibiotics. Tigecycline is typically reserved for complicated infections, including those caused by MRSA, especially when other treatment options may be limited.

Daptomycin also has activity against MRSA and would be another potential choice for treating these infections; however, the focus of the question is specifically on the best option provided. Aminoglycosides primarily target Gram-negative bacteria and have limited effects against MRSA, while piperacillin, though effective against a range of organisms, does not cover MRSA adequately unless combined with a beta-lactamase inhibitor. Therefore, tigecycline stands out as a viable option with good efficacy against MRSA among the choices presented.