What is the first-line treatment for severe lead poisoning?

The first-line treatment for severe lead poisoning is chelation therapy, specifically using EDTA (ethylenediaminetetraacetic acid). Lead poisoning can cause serious health issues, including neurological impairment, especially in children. The primary goal in treating lead poisoning is to reduce the blood lead levels and minimize the associated toxic effects.

EDTA is a chelating agent, which means it binds to heavy metals like lead in the bloodstream and facilitates their excretion through the kidneys. This is particularly effective in cases of severe lead toxicity, as it can rapidly lower lead levels and help alleviate symptoms. EDTA is administered intravenously in a medical setting due to its potency and the need for monitoring during treatment.

Other options for treating lead poisoning, such as deferasirox, are specific to iron overload conditions and are not appropriate for lead. Pyridoxine, while it has some role in treating certain metabolic disorders, is not effective against lead toxicity. Activated charcoal is used in cases of acute poisoning with certain substances, particularly if it is administered shortly after ingestion; however, it is not effective for lead poisoning because lead is not well-absorbed by activated charcoal once it is already in the bloodstream. In severe cases, especially where there is a risk