What is a common feature of pemphigus vulgaris?

Pemphigus vulgaris is characterized by the presence of oral lesions, which is a key feature of this autoimmune blistering disorder. In pemphigus vulgaris, blisters develop not only on the skin but also in the mucous membranes, including the oral cavity. These lesions can be painful and may precede the appearance of dermatological symptoms.

The autoimmune response in pemphigus vulgaris specifically targets desmogleins, which are proteins that help to hold skin cells together. As a result, the epidermis becomes fragile, leading to the formation of blisters that can easily rupture, but the presence of oral lesions distinguishes pemphigus vulgaris from other blistering disorders.

In contrast, the absence of Nikolsky's sign would typically be associated with conditions like bullous pemphigoid, which is a key differentiator between these diseases. Blisters in pemphigus vulgaris are usually quite prone to rupture, not less likely, and while pemphigus vulgaris can occur in adults, it most commonly presents in middle-aged individuals rather than primarily affecting older adults.