What is a classic symptom of Kallmann's syndrome?

Kallmann's syndrome is characterized by a combination of hypogonadotropic hypogonadism and anosmia, which is the loss or absence of the sense of smell. This syndrome results from a failure of the GnRH (gonadotropin-releasing hormone) neurons to migrate from the olfactory bulb during embryonic development, leading to deficiencies in sex hormone production and the associated symptoms of hypogonadism.

The presence of anosmia is a classic and distinguishing feature of Kallmann's syndrome. Patients often report a lack of smell or an inability to detect certain odors. Additionally, they may present with symptoms related to hypogonadism, such as delayed puberty, decreased libido, and infertility due to low levels of sex hormones.

In contrast, the other options listed do not accurately reflect the defining features of Kallmann's syndrome. Gynecomastia typically relates to hormonal imbalances affecting estrogen and testosterone levels but is not a primary symptom of Kallmann's syndrome. Hypergonadism, on the other hand, would imply elevated gonadotropin levels, which is contrary to the presentation of Kallmann's syndrome, where there is a lack of sex hormone stimulation due to hypogonadotropic factors. Persistent phimos