What age group is typically affected by bullous pemphigoid?

Bullous pemphigoid is an autoimmune blistering disorder that primarily affects older adults, particularly those in their 70s and 80s. The condition arises due to the development of antibodies against proteins in the basement membrane of the skin, leading to the formation of blisters that can be painful and itchy.

The age group affected by this condition is significant for several reasons. Older adults tend to have a higher incidence of autoimmune diseases, and the pathophysiology of bullous pemphigoid suggests that the immune system may become dysregulated with age. The typical presentation involves the appearance of large, tense blisters in areas of skin that are prone to friction, and these symptoms are often more pronounced in the elderly population.

Other age groups, such as young adults in their 30s, children, and middle-aged individuals in their 40s, do not generally experience bullous pemphigoid. While other skin conditions can occur in these populations, bullous pemphigoid is characteristically associated with older age, which highlights the importance of recognizing the demographic specific to this disease. Understanding this age-related prevalence is crucial for timely diagnosis and management of the condition.