Drug rashes are generally mediated by which type of immune response?

Drug rashes are generally mediated by which type of immune response?

• A. IgE-mediated response
• B. Complement-mediated response
• C. Lymphocyte-mediated response
• D. Antibody-mediated response

Answer: (C)

The development of drug rashes predominantly involves a lymphocyte-mediated response, particularly through mechanisms involving T cells. When a drug is introduced into the body, it can become haptenized and modify proteins, leading to the activation of T lymphocytes. This can result in delayed-type hypersensitivity reactions, commonly seen in drug eruptions. In these scenarios, specific T cells recognize drug-modified proteins as foreign and initiate an immune response. The infiltration of T cells and their cytokine release can lead to skin rashes, which may vary in presentation from simple maculopapular eruptions to more severe reactions like Stevens-Johnson syndrome. While IgE-mediated responses are typically involved in allergic reactions like anaphylaxis and certain types of urticaria, and antibody-mediated responses generally refer to immediate hypersensitivity or autoimmune conditions, drug rashes primarily reflect a delayed hypersensitivity type of reaction driven by lymphocyte activation. This understanding is crucial as it guides the management of patients presenting with drug-related skin manifestations.

The development of drug rashes predominantly involves a lymphocyte-mediated response, particularly through mechanisms involving T cells. When a drug is introduced into the body, it can become haptenized and modify proteins, leading to the activation of T lymphocytes. This can result in delayed-type hypersensitivity reactions, commonly seen in drug eruptions.

In these scenarios, specific T cells recognize drug-modified proteins as foreign and initiate an immune response. The infiltration of T cells and their cytokine release can lead to skin rashes, which may vary in presentation from simple maculopapular eruptions to more severe reactions like Stevens-Johnson syndrome.

While IgE-mediated responses are typically involved in allergic reactions like anaphylaxis and certain types of urticaria, and antibody-mediated responses generally refer to immediate hypersensitivity or autoimmune conditions, drug rashes primarily reflect a delayed hypersensitivity type of reaction driven by lymphocyte activation. This understanding is crucial as it guides the management of patients presenting with drug-related skin manifestations.